A lipidated form of the extracellular domain of influenza M2 protein as a self-adjuvanting vaccine candidate

W Zeng; ACL Tan; K Horrocks; DC Jackson

Journal article

A lipidated form of the extracellular domain of influenza M2 protein as a self-adjuvanting vaccine candidate

W Zeng, ACL Tan, K Horrocks, DC Jackson

Vaccine | ELSEVIER SCI LTD | Published : 2015

DOI: 10.1016/j.vaccine.2015.05.053

Abstract

The highly conserved extracellular domain of Matrix protein 2 (M2e) of influenza A virus has been previously investigated as a potential target for an universal influenza vaccine. In this study we prepared four lipopeptide influenza vaccine candidates in which the TLR2 agonist S-[2,3-bis(palmitoyloxy)propyl] cysteine, (Pam2Cys) was attached to either the N- or C-terminus of the M2e consensus sequence SLLTEVETPIRNEWGCRCNDSSDP and its analogue sequence with the two cysteine residues replaced with serine residues. The results of animal study show that each of these lipopeptides induced strong M2e-specific antibody responses in the absence of extraneous T helper cell epitope(s) which are normall..

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University of Melbourne Researchers

Weiguang Zeng Author

David Jackson Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

This work was supported by Program Grant 567122 from the National Health and Medical Research Council of Australia. DCJ is a recipient of an NHMRC Research Fellowship APP1042018.